KIN001 reduced formation of leaky blood vessels and reduced retinal fibrosis in preclinical models of wet Age-Related Macular Degeneration
Potential as first oral therapy for wet AMD complementing ocular injections of anti-VEGF targeted drugs
Regulatory approval for Phase 2 clinical trial in wet AMD patients approved in Germany and Switzerland
Basel, Switzerland, May 3, 2022. Kinarus AG, a Swiss clinical-stage biopharmaceutical company announced today preclinical data supporting the potential effectiveness of its lead clinical candidate, KIN001, as an oral treatment for wet age-related macular degeneration (wet AMD). Kinarus has received approval to conduct a Phase 2 clinical trial of KIN001 in wet AMD patients in Germany and Switzerland.
In a mouse model, KIN001 reduced pathological choroidal neovascularization (CNV) after laser-induced retinal damage. KIN001 reduced the growth and leakiness of new blood vessels and reduced histological markers of retinal fibrosis. In a second study, in a nonhuman primate model of AMD, KIN001 reduced the development of clinically relevant stage 4 CNV lesions at two weeks by approximately 75%.
“These preclinical data strongly support the potential of KIN001 to be an effective treatment for wet AMD and other ocular diseases,” said Matthew Wright PhD, Kinarus Head of Research. “Our strategy to explore advanced drugs for new therapeutic uses allows us to move KIN001 directly into a Phase 2 clinical trial in patients. KIN001 is intended to complement ocular injections of anti-vascular endothelial growth factor (anti- VEGF) targeted drugs, potentially reducing the frequency of these burdensome treatments.”
About Wet Age-Related Macular Degeneration
Wet age-related macular degeneration affects the retinal macula, important for central vision. Wet AMD is the leading cause of visual disability in the industrialized world, and the third leading cause worldwide. Current standard of care dictates frequent intravitreal anti-VEGF injections which places a substantial burden on patients, caregivers, and physicians. An oral treatment, that reduces the frequency of injections, may address unmet need by reducing patient burden and providing a therapy in areas of the world lacking anti-VEGF drugs due to issues of cost and access.
KIN001 is an orally administered combination of pamapimod and pioglitazone. Pamapimod is a potent inhibitor of the p38 mitogen-activated protein kinase (MAPK), central for the cellular response in many diseases. Pioglitazone is an activator of the peroxisome proliferator-activated receptor (PPAR) gamma, marketed for the treatment of type 2 diabetes. Kinarus has discovered that the drug combination increases the efficacy and durability of therapeutic response in preclinical models reflecting various diseases. KIN001 is currently being developed in COVID-19, Idiopathic Pulmonary Fibrosis, and wet Age-Related Macular Degeneration.
Kinarus AG is a Swiss clinical-stage biopharmaceutical company focused on bringing differentiated treatments to patients suffering from viral, respiratory, and ophthalmic diseases. Kinarus’ differentiated therapeutic candidate, KIN001, has broad potential in numerous therapeutic areas.
For more information, please visit the company’s website at www.kinarus.com.
CEO, Kinarus AG
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