Age-Related Macular Degeneration

Age-related macular degeneration (AMD) is a chronic eye disorder that causes blurred vision or a blind spot in the visual field. AMD accelerates deterioration of the macula, the part of the retina responsible for capturing light that is critically important for central vision. The underlying cause is the invasion of abnormal new blood vessels from the choroid layer into the macula (choroidal neovascularization). These abnormal blood vessels may leak fluid or blood, interfering with retinal function. AMD is the leading cause of blindness in developed countries.


Wet macular degeneration is one of two types of age-related macular degeneration. The other type—dry macular degeneration—is more common but less severe. Presence of dry macular degeneration always precedes the development of the wet form.

Anti-VEGF medications, administered by direct injection into the eye, have been useful in the treatment of AMD, but unmet needs remain. Intravitreal injections require frequent and ongoing visits to the clinic, with a particularly high burden during the first two years. Despite the progress made with these therapies, real-world data shows that patients are poorly controlled and continue to lose vision.